Thionyl Chloride → 1-Phenyl-cyclopropanecarbonyl chloride

HRID 220228

反応式

HRID 220228 の反応式
[C:1]1([C:7]2([C:10]([OH:12])=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:15])=O>>[C:1]1([C:7]2([C:10]([Cl:15])=[O:12])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 802061-Phenylcyclopropanecarboxylic acid

生成物 1

HCID 27603721-Phenyl-cyclopropanecarbonyl chloride

反応条件

温度
80 °C

実験手順

1-Phenyl-cyclopropanecarboxylic acid (0.5 g, 3.1 mmol), was dissolved in thionyl chloride (10 eq, 0.031 mol, 3.68 g, 2.3 ml), and refluxed at 80° C. for 1.5 hours. Then excess of thionyl chloride was evaporated on the rotary evaporator which yielded a dark-yellowish liquid (1-phenyl-cyclopropanecarbonyl chloride A), which was then cooled to 0° C., under argon.

後処理

  1. customThen excess of thionyl chloride was evaporated on the rotary evaporator which

出典と根拠

ORDレコード
ord-ed53528c209f4d25bd2e6f5417502a4b
出典データセット
uspto-grants-2012_06
特許番号
US08202901B2

関連ノート

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