Tetrahydrofuran → HCID 90447574、化合物

HRID 2202341ノート

反応式

HRID 2202341 の反応式
[CH2:1]([C:4]1([OH:17])[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]1)[CH:2]=[CH2:3].C[Si](C)(C)[C:20]([F:23])(F)[F:21].C1COCC1>C(Cl)Cl>[F:21][C:20]1([F:23])[CH2:3][CH:2]1[CH2:1][C:4]1([OH:17])[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 552549(Trifluoromethyl)trimethylsilaneHCID 21955339Tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate

生成物 1

HCID 90447574HCID 90447574、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
80 °C

実験手順

To a sealed tube was added tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate 11B (280 mg, 1.16 mmol), Nat (112 mg, 0.74 mmol), trimethyl(trifluoromethyl)silane (0.6 mL) and THF (10 mL). The tube was sealed, and then the mixture was stirred at 80° C. overnight. The resulting mixture was diluted with DCM, filtered, and the filtrate was concentrated in vacuo to give the crude product 11C which was used for next step without further purification. LC-MS: m/z 292.3 (M+H)+

後処理

  1. customThe tube was sealed
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-65a7617cd07e448b958f92d8c6467759
出典データセット
uspto-grants-2016_06
特許番号
US09365545B2

反応ノート

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