Benzyl-4-(benzyloxymethoxy)-4-(2-fluoro-2-methylpropyl)piperidine-1-carboxylate → 4-(2-Fluoro-2-methylpropyl)piperidin-4-ol
反応式
C(OC([N:11]1[CH2:16][CH2:15][C:14]([O:22]COCC2C=CC=CC=2)([CH2:17][C:18]([F:21])([CH3:20])[CH3:19])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>[Pd].CO>[F:21][C:18]([CH3:20])([CH3:19])[CH2:17][C:14]1([OH:22])[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1参加物
4
実験手順
To a round bottom flask was added benzyl-4-(benzyloxymethoxy)-4-(2-fluoro-2-methylpropyl)piperidine-1-carboxylate (50 mg, 0.12 mmol), Pd/C (20 mg), and methanol (5 mL). The mixture was stirred at room temperature for 16 hrs under hydrogen atmosphere. The reaction mixture was filtered to get a solution, which was concentrated to give the desired product. The crude product was used directly for the next step. LC-MS: m/z 176.2 (M+H)+
後処理
- filtrationThe reaction mixture was filtered
- customto get a solution, which
- concentrationwas concentrated
出典と根拠
- ORDレコード
- ord-f38e584723774e7588111ac47961082f
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365545B2
反応ノート
読み込み中…