Carbamimidoyl-nitroso-acetic acid ethyl ester → HCID 12439913、化合物
反応式
[CH2:1]([O:3][C:4](=[O:11])[CH:5]([C:8](=[NH:10])[NH2:9])[N:6]=O)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:11])[CH:5]([NH2:6])[C:8](=[NH:9])[NH2:10])[CH3:2]参加物
4
実験手順
To a solution of carbamimidoyl-nitroso-acetic acid ethyl ester (5.5 g, 31.4 mmol) in ethanol/5M HCl (1:1 ratio, 250 ml) was added 10% Pd/C (1.3 g). The reaction mixture was hydrogenated (H2(g)) at low pressure over 2 nights. The Pd/C was filtered through Celite® (filter material) and the filtrate reduced in vacuo to give the title compound as a white solid. This was taken through to the next step as crude.
後処理
- customover 2 nights
- filtrationThe Pd/C was filtered through Celite® (filter material)
出典と根拠
- ORDレコード
- ord-77f8d97b98404fa9a05d1d34c7004809
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365552B2
反応ノート
読み込み中…