[2-(2-Amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester → HCID 178488952、化合物

HRID 220251

反応式

HRID 220251 の反応式
[C:1]([O:5][C:6](=[O:23])[N:7]([CH2:9][CH2:10][C:11](=O)[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[C:14]=1[NH2:21])[CH3:8])([CH3:4])([CH3:3])[CH3:2]>C(O)(=O)C>[C:1]([O:5][C:6](=[O:23])[N:7]([CH2:9][CH2:10][C:11]1[NH:21][C:14]2[C:15]([O:19][CH3:20])=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=1)[CH3:8])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 1

HCID 68411798[2-(2-Amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester

生成物 1

HCID 178488952HCID 178488952、化合物収率 75.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 2.1 g of crude [2-(2-amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester in 10 mL acetic acid was heated at 65° C. for 2 h. The reaction mixture was concentrated and purified by CC with EtOAc to yield 1.5 g of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-carbamic acid tert.-butyl ester as orange foam.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by CC with EtOAc

出典と根拠

ORDレコード
ord-2221cab70cb74afabc02b086ed5cf267
出典データセット
uspto-grants-2012_06
特許番号
US08202885B2

関連ノート

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