Hydrazine hydrate (1:1) → HCID 4164367、化合物
反応式
CS[C:3]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[C:4]([C:7]#[N:8])[C:5]#[N:6].O.[NH2:17][NH2:18]>CCO>[NH2:6][C:5]1[NH:18][N:17]=[C:3]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:4]=1[C:7]#[N:8]参加物
4
実験手順
Dissolved 2-((methylthio)(phenylamino)methylene)malononitrile (3.2 g) in EtOH (100 mL) and added hydrazine hydrate (1 eq), then heated to reflux until complete by TLC (absence of starting material, 18 hrs). Poured into ice water and filtered to obtain 5-amino-3-(phenylamino)-1H-pyrazole-4-carbonitrile as a yellow powder.
後処理
- temperatureheated
- temperatureto reflux until complete by TLC (absence of starting material, 18 hrs)
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-8e924ff2dc0d49d6875015eca47a8806
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365556B2
反応ノート
読み込み中…