Sodium Hydroxide → 3-[4,5-diphenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-propionic acid

HRID 220263ノート

反応式

HRID 220263 の反応式
C[O:2][C:3](=[O:31])[CH2:4][CH2:5][C:6]1[N:7]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[C:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:10]=1.[OH-].[Na+]>C(O)C>[C:11]1([C:9]2[N:10]=[C:6]([CH2:5][CH2:4][C:3]([OH:31])=[O:2])[N:7]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:29])([CH3:28])[CH3:30])[C:8]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 684117713-[4,5-diphenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-propionic acid methyl ester

生成物 1

HCID 684143723-[4,5-diphenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-propionic acid収率 94.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

150 mg of 3-[4,5-diphenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-propionic acid methyl ester were dissolved in 1 mL of ethanol and treated with 0.7 mL of a 1M aq. solution of sodium hydroxide. The mixture was partitioned between water and Et2O. The aq. layer was separated, acidified with 25%-HCl and extracted with DCM. The organic phase was dried over anh. Na2SO4 and concentrated in vacuo to give 137 mg of 3-[4,5-diphenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-propionic acid the product as a white solid.

後処理

  1. customThe mixture was partitioned between water and Et2O
  2. customThe aq. layer was separated
  3. extractionextracted with DCM
  4. dry with materialThe organic phase was dried over anh. Na2SO4
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8c55cd5a7d824a9bbde270638954d690
出典データセット
uspto-grants-2012_06
特許番号
US08202885B2

反応ノート

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