HCID 10176480、化合物 → FURO[2,3-B]PYRIDINE-5-METHANOL
反応式
C([O:3][C:4]([C:6]1[CH:7]=[C:8]2[CH:14]=[CH:13][O:12][C:9]2=[N:10][CH:11]=1)=O)C.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[O:12]1[C:9]2=[N:10][CH:11]=[C:6]([CH2:4][OH:3])[CH:7]=[C:8]2[CH:14]=[CH:13]1参加物
4
反応条件
- 温度
- -20 °C
実験手順
To a solution of 1.9 g of furo[2,3-b]pyridine-5-carboxylic acid ethyl ester (GB 2289276) in 30 ml of THF was added dropwise 17.3 ml of a LiAlH4 (2.3M THF) solution at −20° C. The reaction mixture was stirred for 3 h at −20° C. and then quenched by addition of 1M NaOH solution. The resulting mixture was filtrated over a pad of celite, washed with THF and the filtrate was concentrated in vacuo. Purification by CC using EtOAc yielded 0.5 g of furo[2,3-b]pyridin-5-yl-methanol as yellow oil.
後処理
- customquenched by addition of 1M NaOH solution
- filtrationThe resulting mixture was filtrated over a pad of celite
- washwashed with THF
- concentrationthe filtrate was concentrated in vacuo
- customPurification by CC
出典と根拠
- ORDレコード
- ord-36f0f37fe9dd4c2e82a3f88f2c73150e
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202885B2
反応ノート
読み込み中…