4-(Benzyloxy)-1-(2-ethyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one → 1-(2-Ethyl-1-methyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one

HRID 2202887ノート

反応式

HRID 2202887 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([C:15]2[CH:16]=[CH:17][C:18]3[N:22]=[C:21]([CH2:23][CH3:24])[N:20]([CH3:25])[C:19]=3[CH:26]=2)[C:11](=[O:27])[CH:10]=1)C1C=CC=CC=1>[Pd].CO>[CH2:23]([C:21]1[N:20]([CH3:25])[C:19]2[CH:26]=[C:15]([N:12]3[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]3=[O:27])[CH:16]=[CH:17][C:18]=2[N:22]=1)[CH3:24]

参加物

4

反応物 1

HCID 896910784-(Benzyloxy)-1-(2-ethyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one

生成物 1

HCID 896909981-(2-Ethyl-1-methyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one収率 61,012.898%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 4-(benzyloxy)-1-(2-ethyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one (3.5 mg), Pd/C (10%, 700 mg) and MeOH (10 ml) was stirred under H2 atmosphere at room temperature for 2 h. The insoluble material was removed by filtration, and the filtrate was concentrated to give the title compound (1.6 g) as a white solid.

後処理

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-422084a30eb448718fa93ccdf139e4e7
出典データセット
uspto-grants-2016_06
特許番号
US09365540B2

反応ノート

読み込み中…