Dimethylformamide → Methyl 5-iodothiophene-3-carboxylate
反応式
[I:1][C:2]1[S:6][CH:5]=[C:4]([C:7]([OH:9])=[O:8])[CH:3]=1.IC.[C:12](=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[I:1][C:2]1[S:6][CH:5]=[C:4]([C:7]([O:9][CH3:12])=[O:8])[CH:3]=1参加物
6
実験手順
A mixture of 5-iodothiophene-3-carboxylic acid (3.48 g), iodomethane (2.92 g), potassium carbonate (2.84 g) and DMF (35 ml) was stirred at room temperature for 1 day. The reaction mixture was poured into water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (3.62 g) as a white solid.
後処理
- extractionextracted with EtOAc
- washThe extract was washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated
- custompurified by silica gel column chromatography (hexane/EtOAc)
出典と根拠
- ORDレコード
- ord-ccf7f8e582f54e4aa7d164c2a6422781
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365540B2
反応ノート
読み込み中…