Bromopyruvic Acid → 2-(Ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid
反応式
[NH2:1][C:2](=[S:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Br[CH2:10][C:11](=O)[C:12]([OH:14])=[O:13]>C1COCC1>[CH2:6]([O:5][C:3]([C:2]1[S:8][CH:10]=[C:11]([C:12]([OH:14])=[O:13])[N:1]=1)=[O:4])[CH3:7]参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of ethyl 2-amino-2-thioxoacetate (10.1 g), 3-bromo-2-oxopropanoic acid (12.7 g) and THF (200 ml) was stirred at 50° C. overnight. The mixture was concentrated in vacuo, and the resulting solid was suspended in EtOAc. The precipitate was collected by filtration to give the title compound (7.4 g) as a white solid.
後処理
- concentrationThe mixture was concentrated in vacuo
- filtrationThe precipitate was collected by filtration
出典と根拠
- ORDレコード
- ord-a66a0c4a3d2a46ff8b51d706f7b576c5
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365540B2
反応ノート
読み込み中…