Tetrahydrofuran → Ethyl 4-(hydroxymethyl)-1,3-thiazole-2-carboxylate
反応式
[CH2:1]([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([C:11](O)=[O:12])[N:10]=1)=[O:5])[CH3:2].C1COCC1>CO>[OH:12][CH2:11][C:9]1[N:10]=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[S:7][CH:8]=1参加物
4
実験手順
A mixture of 2-(ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid (2 g), boran-THF complex (1.0 M in THF, 45.2 ml) and THF (50 ml) was heated under reflux overnight. After MeOH (2.0 ml) was added to the mixture at the same temperature, the mixture was concentrated in vacuo to dryness. The residue was purified by NH silica gel column chromatography (hexane/EtOAc) to give the title compound (0.96 g) as a white solid.
後処理
- temperatureunder reflux overnight
- concentrationthe mixture was concentrated in vacuo to dryness
- customThe residue was purified by NH silica gel column chromatography (hexane/EtOAc)
出典と根拠
- ORDレコード
- ord-e496314232ef4df18834c018eb66ffb8
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365540B2
反応ノート
読み込み中…