Ethyl 4-(hydroxymethyl)-1,3-thiazole-2-carboxylate → HCID 117762896、化合物
反応式
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[S:6][CH:7]=1>[O-2].[O-2].[Mn+4].C1COCC1>[CH:2]([C:3]1[N:4]=[C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[S:6][CH:7]=1)=[O:1]参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of ethyl 4-(hydroxymethyl)-1,3-thiazole-2-carboxylate (1.23 g), manganese dioxide (5.71 g) and THF (25 ml) was heated at 50° C. overnight. The inorganic material was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound (1.11 g) as a yellow solid.
後処理
- customThe inorganic material was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-13b540fa9a904ad68b560f2fefb8b9a6
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365540B2
反応ノート
読み込み中…