Sodium borohydride → 2-Thiazolemethanol, 4-(difluoromethyl)-
反応式
[F:1][CH:2]([F:13])[C:3]1[N:4]=[C:5]([C:8](OCC)=[O:9])[S:6][CH:7]=1.[BH4-].[Na+]>CO>[F:1][CH:2]([F:13])[C:3]1[N:4]=[C:5]([CH2:8][OH:9])[S:6][CH:7]=1参加物
4
実験手順
To a solution of ethyl 4-(difluoromethyl)-1,3-thiazole-2-carboxylate (900 mg) in MeOH (15 ml) was added NaBH4 (329 mg), and the mixture was stirred at room temperature for 2 h. The mixture was partitioned between saturated NH4Cl solution and EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo to give the title compound (703 mg) as a colorless oil.
後処理
- customThe mixture was partitioned between saturated NH4Cl solution and EtOAc
- washThe organic layer was washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-cbb5073800864f14a8eaed68c6c1d4f9
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365540B2
反応ノート
読み込み中…