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Triethylamine → 1-(1,2-Dimethyl-1H-imidazole-4-sulfonyl)-1H-pyrazole-4-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1,2-Dimethylimidazole-4-sulfonyl chloride | HCID 2736256 | — |
| 反応物 | 1H-pyrazole-4-carbaldehyde | HCID 5130673 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(1,2-Dimethyl-1H-imidazole-4-sulfonyl)-1H-pyrazole-4-carbaldehyde | HCID 86641654 | — |
反応手順
Dissolve 1H-pyrazole-4-carboxaldehyde (0.150 g, 1.56 mmol) in DCM (5 mL). Add triethylamine (240 μL, 1.72 mmol) and 1,2-dimethyl-1H-imidazole-4-sulfonyl chloride (0.334 g, 1.72 mmol). Stir at ambient temperature for 18 hr. Concentrate, and purify via silica gel chromatography, eluting with 50:50 to 100:0 ethyl acetate:hexanes to give the title preparation (317 mg, 80%). GC-MS: m/z=254 [M+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202873B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-cc181fae01ce40fb981d7af70506a6a3 |
| 出典メモ | uspto-grants-2012_06 |