HCID 12751998、化合物 → HCID 21997827、化合物
反応式
S([N:11]1[CH2:16][C:15](=[O:17])[C:14]2[S:18][CH:19]=[CH:20][C:13]=2[CH2:12]1)(C1C=CC(C)=CC=1)(=O)=O.CC([O-])(C)C.[K+]>OC(C)(C)C>[S:18]1[C:14]2[C:15](=[O:17])[CH2:16][N:11]=[CH:12][C:13]=2[CH:20]=[CH:19]1参加物
4
実験手順
To a solution of 5,6-dihydro-5-tosylthieno[3,2-c]pyridin-7(4H)-one (1.24 g, 4.03 mmol, 1.0 equiv) in HOt-Bu (15.0 mL) was added KOt-Bu (904 mg, 8.06 mmol, 2.0 equiv) and heated to reflux for 2 h. The mixture was quenched with water and then extracted with ethyl acetate. Purification by column chromatography using 50% ethyl acetate in hexanes elution gave 1.09 g of white solid, 89%.
後処理
- temperatureheated
- temperatureto reflux for 2 h
- customThe mixture was quenched with water
- extractionextracted with ethyl acetate
- customPurification by column chromatography
- wash50% ethyl acetate in hexanes elution
出典と根拠
- ORDレコード
- ord-10fd11161bfb49b28cfab075769b61ac
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09370515B2
反応ノート
読み込み中…