HCID 12751998、化合物 → HCID 90388426、化合物

反応式

[Li][CH2:2]CCC.[S:6]([N:16]1[CH2:21][C:20](=O)[C:19]2[S:23][CH:24]=[CH:25][C:18]=2[CH2:17]1)([C:9]1[CH:15]=[CH:14][C:12]([CH3:13])=[CH:11][CH:10]=1)(=[O:8])=[O:7]>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1COCC1>[CH2:2]=[C:20]1[CH2:21][N:16]([S:6]([C:9]2[CH:15]=[CH:14][C:12]([CH3:13])=[CH:11][CH:10]=2)(=[O:8])=[O:7])[CH2:17][C:18]2[CH:25]=[CH:24][S:23][C:19]1=2

参加物

実験手順

To a solution of methyltriphenylphosphonium bromide (2.05 g, 5.73 mmol, 2.0 equiv) in THF (10.0 mL) at −78° C. was added n-BuLi (3.58 mL, 1.6 M solution, 2.0 equiv) and stirred for 30 min followed by addition of 5,6-dihydro-5-tosylthieno[3,2-c]pyridin-7(4H)-one (880 mg, 2.86 mmol, 1.0 equiv) in THF (5.00 mL). The reaction mixture was stirred at rt for 1 h, then quenched by the addition of a saturated aqueous solution of ammonium chloride. Purification by column chromatography using 5% ethyl acetate in hexanes elution gave 175 mg of the yellow solid, 20%.