Potassium tert-butoxide → HCID 13351954、化合物
反応式
[CH2:1]=[C:2]1[CH2:7][N:6](S(C2C=CC(C)=CC=2)(=O)=O)[CH2:5][C:4]2[CH:18]=[CH:19][S:20][C:3]1=2.CC([O-])(C)C.[K+]>OC(C)(C)C>[CH3:1][C:2]1[C:3]2[S:20][CH:19]=[CH:18][C:4]=2[CH:5]=[N:6][CH:7]=1参加物
4
実験手順
To a solution of 4,5,6,7-tetrahydro-7-methylene-5-tosylthieno[3,2-c]pyridine (150 mg, 0.491 mmol, 1.0 equiv) in HOt-Bu (5 mL) was added KOt-Bu (110 mg, 0.982 mmol, 2.0 equiv) and heated to reflux for 3 h. Purification by column chromatography using ethyl acetate elution gave 62 mg of the yellow solid, 85%.
後処理
- temperatureheated
- temperatureto reflux for 3 h
- customPurification by column chromatography
- washethyl acetate elution
出典と根拠
- ORDレコード
- ord-8b76e2885cd24cc2905e578c53cb89bd
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09370515B2
反応ノート
読み込み中…