Indole → (E)-12-methyl-7,8,9,10,13a, 14-hexahydroazecino[1,2-a]indol-6(13H)-one

HRID 2205256

反応式

HRID 2205256 の反応式
[CH2:1]=[C:2]([CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C:5]1=[O:10])[CH3:3].[NH:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12]1.N1C2C(=CC=CC=2)CC=1.C([Al](Cl)Cl)C>ClCCCl>[CH3:1][C:2]1[CH2:3][CH:12]2[CH2:13][C:14]3[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:11]2[C:5](=[O:10])[CH2:6][CH2:7][CH2:8][CH2:9][CH:4]=1

参加物

6

反応物 4

HCID 798IndoleHCID 11237Ethylaluminum dichlorideHCID 30835603H-IndoleHCID 11018939Cyclohexanone, 2-(1-methylethenyl)-

生成物 1

HCID 131735804(E)-12-methyl-7,8,9,10,13a, 14-hexahydroazecino[1,2-a]indol-6(13H)-one収率 77%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

Following the general procedure as described in Example 17, 2-(prop-1-en-2-yl)cyclohexanone (0.88 g, 6.38 mmol), 1H-indole (0.90 g, 7.65 mmol) which was in situ isomerized to 3H-indole, and EtAlCl2 (0.81 g, 6.38 mmol) in 1,2-dichloroethane (65 ml) were reacted to give the title product as a white solid (1.25 g, 77% yield).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-9db42c8f2994453d8750ec9104891608
出典データセット
uspto-grants-2016_06
特許番号
US09371262B2

関連ノート

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