Hydrazine hydrate (1:1) → N-(4-(6-hydrazinylpyridazin-3-yl)phenyl)methanesulfonamide
反応式
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O.[NH2:20][NH2:21]>>[NH:20]([C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1)[NH2:21]参加物
3
実験手順
A suspension of N-(4-(6-chloropyridazin-3-yl)phenyl)methanesulfonamide (2.82 mmole) in hydrazine monohydrate (6 mL) was heated at 120 C for 1 hour and evaporated in vacuo. The residue was dissolved in dichloromethane, washed with water, dried over Na2SO4, and evaporated in vacuo to afford N-(4-(6-hydrazinylpyridazin-3-yl)phenyl)methanesulfonamide.
後処理
- temperaturewas heated at 120 C for 1 hour
- customevaporated in vacuo
- dissolutionThe residue was dissolved in dichloromethane
- washwashed with water
- dry with materialdried over Na2SO4
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-4f948cb74dec416c985330b0db71b059
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09371329B2
反応ノート
読み込み中…