Acetic Anhydride → Methyl 2-[5-acetamido-3-(3-pyridyl)pyrazol-1-yl]acetate

HRID 2205794ノート

反応式

HRID 2205794 の反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][C:9]1[N:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[N:12]=[C:11]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:10]=1>N1C=CC=CC=1>[C:1]([NH:8][C:9]1[N:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[N:12]=[C:11]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:10]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 86717291Methyl 2-[5-amino-3-(3-pyridyl)pyrazol-1-yl]acetate

生成物 1

HCID 86717292Methyl 2-[5-acetamido-3-(3-pyridyl)pyrazol-1-yl]acetate収率 71.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Acetic anhydride (431 μL, 4.4 mmol) was added dropwise to a solution of methyl 2-[5-amino-3-(3-pyridyl)pyrazol-1-yl]acetate (510 mg, 2.2 mmol) in pyridine (1.7 mL) at 0° C. under an atmosphere of nitrogen. Upon complete addition, the reaction mixture was warmed to room temperature and stirred for 16 h. The reaction mixture was filtered and the solid was washed with diethyl ether to provide the title compound as a white solid (430 mg).

後処理

  1. additionUpon complete addition
  2. filtrationThe reaction mixture was filtered
  3. washthe solid was washed with diethyl ether

出典と根拠

ORDレコード
ord-7c2eb639bfbd45288f8837f8d23139a3
出典データセット
uspto-grants-2016_06
特許番号
US09371332B2

反応ノート

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