Dimethylamine → 1-(3-Methoxy-4-nitrophenyl)-N,N-dimethylmethanamine
反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[C:5]([O:12][CH3:13])[CH:4]=1.[CH2:14]([N:16](CC)[CH2:17]C)C.CNC>C1COCC1>[CH3:13][O:12][C:5]1[CH:4]=[C:3]([CH2:2][N:16]([CH3:17])[CH3:14])[CH:8]=[CH:7][C:6]=1[N+:9]([O-:11])=[O:10]参加物
5
実験手順
To a stirred solution of 4-(bromomethyl)-2-methoxy-1-nitrobenzene (Preparation 104, 0.2 g, 0.813 mmol) in dry THF (5 ml), was added triethylamine (0.1 g, 1 mmol) followed by a solution of dimethylamine in THF (0.5 ml of a 2M solution, 1 mmol). After stirring for 1 hour at room temperature, the solvent was removed in vacuum and the crude product was purified by silica gel column chromatography eluting with 10% methanol in ethyl acetate to afford the title compound as a white powder (0.16 g, 94%).
後処理
- customthe solvent was removed in vacuum
- customthe crude product was purified by silica gel column chromatography
- washeluting with 10% methanol in ethyl acetate
出典と根拠
- ORDレコード
- ord-95f977f51e534eabbf4a657d090ac1ed
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09371319B2
反応ノート
読み込み中…