Hydrochloric Acid → 2-Nitro-1-[3-(trifluoromethyl)phenyl]ethanamine hydrochloride

HRID 220633

反応式

HRID 220633 の反応式
[N+:1]([CH2:4][CH:5]([NH:16]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)([O-:3])=[O:2].[ClH:24]>O1CCOCC1>[ClH:24].[N+:1]([CH2:4][CH:5]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:13])([F:14])[F:15])[CH:7]=1)[NH2:16])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 59536870tert-Butyl {2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

生成物 1

HCID 686464472-Nitro-1-[3-(trifluoromethyl)phenyl]ethanamine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Of the compound from Example 12A, 340 mg (1.02 mmol) were admixed at RT with 6.8 ml of a 4N solution of hydrogen chloride in dioxane, and stirred for 1 h. The reaction mixture was concentrated under reduced pressure and dried in an HV. This gave 274 mg (99% of theory) of the title compound.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried in an HV

出典と根拠

ORDレコード
ord-9f140f45327940efaf8114ff642eb124
出典データセット
uspto-grants-2012_06
特許番号
US08202895B2

関連ノート

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