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HRID 220698作成日：2026年10月25日
Potassium cyanate → N-{2-(Carbamoylamino)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide
https://huagongshe.com/reaction/220698
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium cyanate | HCID 11378442 | — |
| 反応物 | N-{2-Amino-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide hydrochloride | HCID 46929233 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | N-{2-(Carbamoylamino)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide | HCID 59536760 | — |
反応手順
Of the compound from Example 11, 266 mg (0.45 mmol) were introduced in 6 ml of methanol/water 1:1 and admixed with potassium cyanate (110 mg, 1.36 mmol) at RT. The mixture was heated at 40° C. for 90 min. Following complete reaction, the mixture was cooled to RT and purified completely by preparative HPLC (Method 10). Drying in an HV gave 232 mg (84% of theory) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08202895B2 |
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| 出典データセット | uspto-grants-2012_06 |
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| ORD ID | ord-42a1b7b0130441aea3295c60497b2674 |
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| 出典メモ | uspto-grants-2012_06 |
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