Potassium cyanate → N-{2-(Carbamoylamino)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

関与物質

反応条件

反応手順

Of the compound from Example 12, 180 mg (0.31 mmol) were introduced in 3 ml of methanol/water 1:1 and admixed with potassium cyanate (75 mg, 0.92 mmol) at RT. The mixture was heated at 40° C. for 90 min. The methanol was removed on a rotary evaporator and the aqueous residue was diluted with 20 ml of water. The precipitated solid was isolated by filtration, washed with a little water and dried in an HV. This gave 146 mg (76% of theory) of the title compound.

情報源と証拠