(3-tert-Butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester → HCID 54100600、化合物

HRID 2207118ノート

反応式

HRID 2207118 の反応式
[CH3:1][O:2][C:3](=[O:17])[CH:4]=[C:5]1[CH2:8][CH:7]([NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6]1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:6][CH:7]([NH:9][C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])[CH2:8]1

参加物

4

反応物 1

HCID 23374583(3-tert-Butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester

生成物 1

HCID 54100600HCID 54100600、化合物収率 99.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (3-tert-butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester (7 g, 29 mmol) in methanol (100 mL) was added Pd/C (5 g) and stirred at room temperature under H2 balloon overnight. After TLC showed the reaction was completed, the mixture was filtered over Celite. The filtrate was concentrated under reduced pressure to give the title compound (7 g, yield 99%) as a white solid, which was used for the next step directly without further purification.

後処理

  1. filtrationthe mixture was filtered over Celite
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-6e18f4d66b88470a8fd066211ed8a7bd
出典データセット
uspto-grants-2016_06
特許番号
US09376396B2

反応ノート

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