Thionyl Chloride → 3-Bromo-4-(chloromethyl)pyridine

HRID 2207143ノート

反応式

HRID 2207143 の反応式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8]O.S(Cl)([Cl:12])=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][Cl:12]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 46840038(3-Bromopyridin-4-yl)methanol

生成物 1

HCID 669333093-Bromo-4-(chloromethyl)pyridine収率 118.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-bromo-4-(hydroxymethyl)pyridine (1.6 g, 8.4 mmol) in methylene chloride (90 mL) was added thionyl dichloride (1.6 mL, 22.0 mmol) dropwise over at 0° C. The reaction was stirred at room temperature for 2 h and then concentrated. The yellow solid was dried in a vacuum to afford the compound 5 (2.05 g, 100%).

後処理

  1. concentrationconcentrated
  2. customThe yellow solid was dried in a vacuum

出典と根拠

ORDレコード
ord-34289a9d3a81428eb86bfa29c3d4b45d
出典データセット
uspto-grants-2016_06
特許番号
US09376387B2

反応ノート

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