Water → 6-phenoxypyridazin-3(2H)-one
反応式
[OH2:1].Cl[C:3]1[N:4]=[N:5][C:6]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:7][CH:8]=1.[OH-].[Na+]>C(O)=O>[O:9]([C:6]1[CH:7]=[CH:8][C:3](=[O:1])[NH:4][N:5]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1参加物
5
反応条件
- 温度
- 95 °C
実験手順
3.1 21 ml of water are added to a solution of 3.10 g (15.0 mmol) of 3-chloro-6-phenoxypyridazine in 21 ml of formic acid, and the mixture is heated at 95° C. for 85 hours. The reaction mixture is cooled and brought to a pH of 6 using 23% aqueous sodium hydroxide solution. The precipitate formed is filtered off with suction, washed with water and dried in vacuo, giving 6-phenoxy-2H-pyridazin-3-one as colourless crystals; ESI 189.
後処理
- temperatureThe reaction mixture is cooled
- customThe precipitate formed
- filtrationis filtered off with suction
- washwashed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-0042a0beed844181b2b4e38345eb5b6f
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09376426B2
反応ノート
読み込み中…