1,2-Dichloroethane → 3-Methyl-N-[5'-(pyridin-3-yl)-2'-methyl-biphenyl-4-yl]-isonicotinamide

HRID 220754

反応式

HRID 220754 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1.C(Cl)CCl.[CH3:25][C:26]1[CH:34]=[N:33][CH:32]=[CH:31][C:27]=1[C:28](O)=[O:29]>C(Cl)Cl>[CH3:25][C:26]1[CH:34]=[N:33][CH:32]=[CH:31][C:27]=1[C:28]([NH:20][C:17]1[CH:16]=[CH:15][C:14]([C:3]2[CH:4]=[C:5]([C:8]3[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=3)[CH:6]=[CH:7][C:2]=2[CH3:1])=[CH:19][CH:18]=1)=[O:29]

参加物

5

反応物 3

HCID 111,2-DichloroethaneHCID 15020033-Methyl-isonicotinic acidHCID 58683777HCID 58683777、化合物

生成物 1

HCID 115889723-Methyl-N-[5'-(pyridin-3-yl)-2'-methyl-biphenyl-4-yl]-isonicotinamide収率 88%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Amide Coupling Reaction: To a solution of 2′-methyl-5′-(pyridin-3-yl)biphenyl-4-amine n (40 mg, 0.15 mmol) in DCM (3 mL) was added EDC (85 mg, 0.45 mmol) and 3-methylisonicotinic acid (40 mg, 0.3 mmol). The solution was stirred at room temperature for 6 hr before it was concentrated and chromatographied to give Compound 20 (50 mg, 88%).

後処理

  1. concentrationwas concentrated

出典と根拠

ORDレコード
ord-5c55252fea5048a0b18958b4ccbb0a6b
出典データセット
uspto-grants-2012_06
特許番号
US08202999B2

関連ノート

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