化工社化工社 化学情報印刷レポート · 研究参考用
1,2-Dichloroethane → 3-Methyl-N-[5'-(pyridin-3-yl)-2'-methyl-biphenyl-4-yl]-isonicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dichloroethane | HCID 11 | — |
| 反応物 | 3-Methyl-isonicotinic acid | HCID 1502003 | — |
| 反応物 | HCID 58683777 | HCID 58683777 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Methyl-N-[5'-(pyridin-3-yl)-2'-methyl-biphenyl-4-yl]-isonicotinamide | HCID 11588972 | 88% |
反応手順
Amide Coupling Reaction: To a solution of 2′-methyl-5′-(pyridin-3-yl)biphenyl-4-amine n (40 mg, 0.15 mmol) in DCM (3 mL) was added EDC (85 mg, 0.45 mmol) and 3-methylisonicotinic acid (40 mg, 0.3 mmol). The solution was stirred at room temperature for 6 hr before it was concentrated and chromatographied to give Compound 20 (50 mg, 88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202999B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-5c55252fea5048a0b18958b4ccbb0a6b |
| 出典メモ | uspto-grants-2012_06 |