Sodium Azide → 4-Azidomethyl-3-fluorobenzoic acid methyl ester
反応式
[N-:1]=[N+:2]=[N-:3].[Na+].[CH3:5][O:6][C:7](=[O:17])[C:8]1[CH:13]=[CH:12][C:11]([CH2:14]Br)=[C:10]([F:16])[CH:9]=1>CN(C=O)C.CCOC(C)=O>[CH3:5][O:6][C:7](=[O:17])[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:1]=[N+:2]=[N-:3])=[C:10]([F:16])[CH:9]=1参加物
5
実験手順
Sodium azide (609 mg) was added to a solution of 4-bromomethyl-3-fluorobenzoic acid methyl ester from Example E3.2 (2.1 g, 8.5 mmol) in DMF (30 ml). The mixture was stirred for 18 h, diluted with EtOAc, washed with water and brine and concentrated in vacuo to give a colourless oil identified as the title compound (1.8 g, 100%).
後処理
- washwashed with water and brine
- concentrationconcentrated in vacuo
- customto give a colourless oil
出典と根拠
- ORDレコード
- ord-e9a6428177bc43d1a2905c16a88ea4c3
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202858B2
反応ノート
読み込み中…