Sodium Hydroxide → 4-((((Tert-butoxy)carbonyl)amino)methyl)-3-fluorobenzoic acid

HRID 220772ノート

反応式

HRID 220772 の反応式
C[O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[C:6]([F:19])[CH:5]=1.[OH-].[Na+]>O1CCOCC1.CCOC(C)=O>[C:15]([O:14][C:12]([NH:11][CH2:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:20])=[O:2])=[CH:5][C:6]=1[F:19])=[O:13])([CH3:18])([CH3:16])[CH3:17]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 597677014-(tert-Butoxycarbonylamino-methyl)-3-fluorobenzoic Acid Methyl Ester

生成物 1

HCID 230231654-((((Tert-butoxy)carbonyl)amino)methyl)-3-fluorobenzoic acid収率 100.4%

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 4-(tert-butoxycarbonylamino-methyl)-3-fluorobenzoic acid methyl ester from Example E3.5 (640 mg, 2.25 mmol) in dioxan (40 ml) was added 1N NaOH (4.5 ml, 4.5 mmol). The mixture was stirred for 18 h, diluted with EtOAc, washed with 1N KHSO4, water and brine and concentrated in vacuo to give a white solid identified as the title compound (608 mg, 100%).

後処理

  1. washwashed with 1N KHSO4, water and brine
  2. concentrationconcentrated in vacuo
  3. customto give a white solid

出典と根拠

ORDレコード
ord-55e658be137d45bfb84319c930d0d0ac
出典データセット
uspto-grants-2012_06
特許番号
US08202858B2

反応ノート

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