Thionyl Chloride → 3-(3-Bromo-4-fluoro-phenyl)-acryloyl chloride

HRID 2207879ノート

反応式

HRID 2207879 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]([OH:13])=O)[CH:5]=[CH:6][C:7]=1[F:8].S(Cl)([Cl:16])=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]([Cl:16])=[O:13])[CH:5]=[CH:6][C:7]=1[F:8]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 6883113-(3-Bromo-4-fluorophenyl)-2-propenoic acid

生成物 1

HCID 27569963-(3-Bromo-4-fluoro-phenyl)-acryloyl chloride

反応条件

温度
100 °C

実験手順

3-(3-Bromo-4-fluoro-phenyl)-acrylic acid (3.3 g, 13.3 mmol) prepared in Step 1 was added to thionyl chloride (10.0 mL). The reaction mixture was stirred at 100° C. for 2 hours, concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 3.5 g of the titled compound as an unpurified dark brown liquid.

後処理

  1. concentrationconcentrated under reduced pressure
  2. concentrationThe resulting residue was concentrated under reduced pressure three times, along with using toluene

出典と根拠

ORDレコード
ord-1bc6024e22d84855b8396c2585ada29d
出典データセット
uspto-grants-2016_06
特許番号
US09376420B2

反応ノート

読み込み中…