Malonic Acid → 3-(5-Bromopyridin-3-yl)prop-2-enoic acid
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=O)[CH:5]=[N:6][CH:7]=1.C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13].N1CCCCC1>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:11][C:12]([OH:14])=[O:13])[CH:5]=[N:6][CH:7]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
5-Bromo-pyridin-3-carbaldehyde (15.0 g, 80.6 mmol), malonic acid (18.9 g, 181.4 mmol), and piperidine (6.6 mL, 66.9 mmol) were added to pyridine (48.9 mL). The reaction mixture was stirred at 100° C. for 1 hour, concentrated under reduced pressure, and then distilled water was added thereto. The mixture was filtered and then the resulting solid was dried under reduced pressure to give 28.4 g of the titled compound as a white solid.
後処理
- concentrationconcentrated under reduced pressure
- additiondistilled water was added
- filtrationThe mixture was filtered
- customthe resulting solid was dried under reduced pressure
出典と根拠
- ORDレコード
- ord-cef87d08cec1481d9c16f09a397af3e0
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09376420B2
反応ノート
読み込み中…