Thionyl Chloride → 3-(5-Bromo-pyridin-3-yl)-acryloyl chloride

HRID 2207893ノート

反応式

HRID 2207893 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([OH:12])=O)[CH:5]=[N:6][CH:7]=1.S(Cl)([Cl:15])=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([Cl:15])=[O:12])[CH:5]=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 27847353-(5-Bromopyridin-3-yl)prop-2-enoic acid

生成物 1

HCID 1317359453-(5-Bromo-pyridin-3-yl)-acryloyl chloride

反応条件

温度
100 °C

実験手順

3-(5-Bromo-pyridin-3-yl)-acrylic acid (26.2 g, 114.7 mmol) prepared in Step 1 was added to thionyl chloride (100.0 mL). The reaction mixture was stirred at 100° C. for 2 hours and then concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 3-(5-bromo-pyridin-3-yl)-acryloyl chloride as an unpurified dark brown liquid.

後処理

  1. concentrationconcentrated under reduced pressure
  2. concentrationThe resulting residue was concentrated under reduced pressure three times, along with using toluene

出典と根拠

ORDレコード
ord-01fe754c286948e4b62d352405604faf
出典データセット
uspto-grants-2016_06
特許番号
US09376420B2

反応ノート

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