Malonic Acid → HCID 54545488、化合物

HRID 2207897ノート

反応式

HRID 2207897 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=O)[CH:3]=1.C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13].N1CCCCC1>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=[CH:11][C:12]([OH:14])=[O:13])[CH:3]=1

参加物

5

反応物 3

HCID 867Malonic AcidHCID 8082PiperidineHCID 147614724-Bromopyridine-2-carbaldehyde

生成物 1

HCID 54545488HCID 54545488、化合物収率 51.6%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
100 °C

実験手順

4-Bromo-pyridin-2-carbaldehyde (10.0 g, 53.5 mmol), malonic acid (12.5 g, 120.5 mmol), and piperidine (4.4 mL, 44.4 mmol) were added to pyridine (32.5 mL). The reaction mixture was stirred at 100° C. for 1 hour, concentrated under reduced pressure, and then distilled water was added thereto. The mixture was filtered and then the resulting solid was dried under reduced pressure to give 6.3 g of the titled compound as a white solid.

後処理

  1. concentrationconcentrated under reduced pressure
  2. additiondistilled water was added
  3. filtrationThe mixture was filtered
  4. customthe resulting solid was dried under reduced pressure

出典と根拠

ORDレコード
ord-091fc3bf3e084bee88f4371705bbfb63
出典データセット
uspto-grants-2016_06
特許番号
US09376420B2

反応ノート

読み込み中…