Thionyl Chloride → HCID 118432046、化合物

HRID 2207948ノート

反応式

HRID 2207948 の反応式
[Br:1][C:2]1[S:6][C:5]([CH:7]2[N:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])[N:10]=[C:9]([C:19]([OH:21])=O)[CH2:8]2)=[CH:4][CH:3]=1.S(Cl)([Cl:24])=O>>[Br:1][C:2]1[S:6][C:5]([CH:7]2[N:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])[N:10]=[C:9]([C:19]([Cl:24])=[O:21])[CH2:8]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 69500037HCID 69500037、化合物

生成物 1

HCID 118432046HCID 118432046、化合物

実験手順

5-(5-Bromo-thiophen-2-yl)-1-(2-chloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid (18.1 g, 46.9 mmol) prepared in Step 4 was added to thionyl chloride (200.0 mL). The reaction mixture was stitted at 100° C. for 2 hours and then concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 5-(5-bromo-thiophen-2-yl)-1-(2-chloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl chloride as a dark brown liquid.

後処理

  1. concentrationconcentrated under reduced pressure
  2. concentrationThe resulting residue was concentrated under reduced pressure three times, along with using toluene

出典と根拠

ORDレコード
ord-0fff55a2cc04434795bae7e37ac14bc0
出典データセット
uspto-grants-2016_06
特許番号
US09376420B2

反応ノート

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