2-Chloromethyl 2-(trimethylsilyl)ethyl ether → Ethyl 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate

HRID 2208174ノート

反応式

HRID 2208174 の反応式
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[C:12]2[NH:19][C:18]([CH3:20])=[C:17]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:13]=2[N:14]=[CH:15][N:16]=1)[CH3:2].Cl[CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[C:12]2[N:19]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[C:18]([CH3:20])=[C:17]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:13]=2[N:14]=[CH:15][N:16]=1)[CH3:2]

参加物

3

反応物 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 67955344ethyl 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate

生成物 1

HCID 67956324Ethyl 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate

実験手順

Starting from ethyl 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (example D.a4) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil.

出典と根拠

ORDレコード
ord-b76092d3c4a540e09f7172add95710d6
出典データセット
uspto-grants-2016_06
特許番号
US09376442B2

反応ノート

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