Trifluoroacetic acid → 4-(4-Methoxycarbonyl-butyl)-3-methyl-benzoic Acid
反応式
FC(F)(F)C(O)=O.C([O:12][C:13](=[O:29])[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[C:16]([CH3:28])[CH:15]=1)(C)(C)C>ClCCl>[CH3:27][O:26][C:24]([CH2:23][CH2:22][CH2:21][CH2:20][C:17]1[CH:18]=[CH:19][C:14]([C:13]([OH:29])=[O:12])=[CH:15][C:16]=1[CH3:28])=[O:25]参加物
4
実験手順
Trifluoroacetic acid (20 ml) was added to a solution of 4-(4-methoxycarbonyl-butyl)-3-methyl-benzoic acid tert-butyl ester from Example E31.3 (1.43 g, 4.7 mmol) in di-chloromethane (40 ml) and the mixture was stirred for 2 h at room temperature. Solvents were concentrated in vacuo and azeotroped with dichloromethane to yield the title compound (1.07 g, 92%).
後処理
- concentrationSolvents were concentrated in vacuo
- customazeotroped with dichloromethane
出典と根拠
- ORDレコード
- ord-ee9f03a88a234524b626194affa8090b
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202858B2
反応ノート
読み込み中…