Trifluoroacetic acid → 2-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid

HRID 220828ノート

反応式

HRID 220828 の反応式
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10](=[O:26])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])=[C:13]([CH3:25])[CH:12]=1>ClCCl>[CH3:8][O:9][C:10](=[O:26])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[C:13]([CH3:25])[CH:12]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 575554334-Tert-butoxycarbonylmethyl-3-methyl-benzoic acid methyl ester

生成物 1

HCID 575552242-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid収率 81%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (15 ml) was added to a solution of 4-tert-butoxycarbonylmethyl-3-methyl-benzoic acid methyl ester from Example E32.1 (2.84 g, 10.7 mmol) in dichloromethane (15 ml). The mixture was stirred for 90 min at room temperature, concentrated in vacuo and azeotroped with toluene. The residue was recrystallised from EtOAc and hexane to yield the title compound (1.81 g, 81%).

後処理

  1. concentrationconcentrated in vacuo
  2. customazeotroped with toluene
  3. customThe residue was recrystallised from EtOAc and hexane

出典と根拠

ORDレコード
ord-40ffc1f9c1c244aa81ff6b3c5a9e1bdd
出典データセット
uspto-grants-2012_06
特許番号
US08202858B2

反応ノート

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