Trifluoroacetic acid → 4-Carboxymethoxy-3-methyl-benzoic Acid Methyl Ester
反応式
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10](=[O:27])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])=[C:13]([CH3:26])[CH:12]=1>ClCCl>[CH3:8][O:9][C:10](=[O:27])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[C:13]([CH3:26])[CH:12]=1参加物
4
実験手順
Trifluoroacetic acid (20 ml) was added to a solution of 4-tert-butoxycarbonylmethoxy-3-methyl-benzoic acid methyl ester from Example E41.1 (3.8 g, 13.6 mmol) in di-chloromethane (40 ml) and the mixture was stirred for 1 h at room temperature. Volatiles were removed in vacuo and azeotroped with dichloromethane to yield the title compound (3.04 g, 100%).
後処理
- customVolatiles were removed in vacuo
- customazeotroped with dichloromethane
出典と根拠
- ORDレコード
- ord-213e6bd1296e41729536b74672aab7b8
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202858B2
反応ノート
読み込み中…