Trifluoroacetic acid → Methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate TFA salt
反応式
[CH2:1]([N:3]([C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[C:19]([C:27]([O:29][CH3:30])=[O:28])[C:18]=1[CH3:31])[CH:4]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)[CH3:2].[C:32]([OH:38])([C:34]([F:37])([F:36])[F:35])=[O:33]>C(Cl)Cl>[OH:38][C:32]([C:34]([F:37])([F:36])[F:35])=[O:33].[CH2:1]([N:3]([CH:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)[C:17]1[C:18]([CH3:31])=[C:19]([CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[C:27]([O:29][CH3:30])=[O:28])[CH3:2]参加物
4
実験手順
To a stirred solution of tert-butyl 4-{ethyl[3-(methoxycarbonyl)-2-methyl-5-(trifluoromethyl)phenyl]amino}piperidine-1-carboxylate (4.50 g, 10.1 mmol) in CH2Cl2 (50 mL) was added TFA (5 mL). The reaction mixture was stirred at rt for 18 hours. Then reaction mixture was concentrated in vacuo to give the titled compound as a crude product (7.70 g).