Hydrochloric Acid → 5-Bromo-2,4-dimethylbenzoic acid

HRID 2208747

反応式

HRID 2208747 の反応式
[OH-].[Na+].[Br:3]Br.[CH3:5][C:6]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].Cl>O>[Br:3][C:12]1[C:13]([CH3:15])=[CH:14][C:6]([CH3:5])=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 118972,4-Dimethylbenzoic acidHCID 14798Sodium HydroxideHCID 24408Bromine

生成物 1

HCID 5557655-Bromo-2,4-dimethylbenzoic acid収率 65%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To the stirred solution of NaOH (60 g) in water (1152 ml) was added bromine (36 ml) dropwise at 0° C. and stirred the reaction mixture for 45 min. at same temperature. 2,4-dimethylbenzoic acid (12 g, 79.9 mmol) was added in above reaction mixture at 0° C. portion wise and stirred the reaction at room temperature for 3 h. After completion of reaction of reaction (TLC) reaction mixture was acidified using conc. HCl, solid was filtered through Buchner funnel and wash with water and dried to afford the desired compound (12 g, 65%) which was used without further purification.

後処理

  1. stirringstirred
  2. customthe reaction at room temperature for 3 h
  3. customAfter completion of reaction of reaction (TLC) reaction mixture
  4. filtrationwas filtered through Buchner funnel
  5. washwash with water
  6. customdried

出典と根拠

ORDレコード
ord-00b87eac2bba4f85bd7b141eb07d33cf
出典データセット
uspto-grants-2016_06
特許番号
US09376422B2

関連ノート

読み込み中…