Nitric Acid → Methyl 5-bromo-2-methyl-3-nitrobenzoic acid

HRID 2208748

反応式

HRID 2208748 の反応式
[Br:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].OS(O)(=O)=O.[N+:18]([O-])([OH:20])=[O:19]>>[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([N+:18]([O-:20])=[O:19])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

参加物

4

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric Acid2 回HCID 5557655-Bromo-2,4-dimethylbenzoic acid

生成物 1

HCID 86623945Methyl 5-bromo-2-methyl-3-nitrobenzoic acid収率 91%

反応条件

温度
-10 °C

実験手順

5-Bromo-2,4-dimethylbenzoic acid (12 g, 52.17 mmol) was added to cooled conc. H2SO4 (48 mL) at −10° C. lot wise. After 10 minutes nitrating mixture {prepared as mixing Conc. HNO3 (6 mL) with conc.H2SO4 (24 mL)} was added drop wise at −10° C. Resulting reaction mass was stirred at −10° C. for 30 minutes. On completion, reaction mixture was poured on ice cold water, solid precipitated was filtered, washed with water and dried under vacuum giving desired compound (13 g, 91%).

後処理

  1. custommixture {prepared
  2. customResulting
  3. customreaction mass
  4. customOn completion, reaction mixture
  5. additionwas poured on ice cold water, solid
  6. customprecipitated
  7. filtrationwas filtered
  8. washwashed with water
  9. customdried under vacuum

出典と根拠

ORDレコード
ord-605d50c7682244c88c1ca871eeafdb64
出典データセット
uspto-grants-2016_06
特許番号
US09376422B2

関連ノート

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