Sodium Hydroxide → 4-[4-[4-(4-Pyridyl)piperazin-1-yl]phenoxy]butyric acid

HRID 2209

反応式

HRID 2209 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[OH-:20].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][N:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:13][CH2:14][CH2:15][C:16]([OH:19])=[O:20])=[CH:15][CH:14]=3)[CH2:11][CH2:12]2)=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 149869034-(4-(4-Pyridyl)piperazin-1-yl)phenol

生成物 1

HCID 189185114-[4-[4-(4-Pyridyl)piperazin-1-yl]phenoxy]butyric acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of the product of Example 25 (0.1 g) in aqueous sodium hydroxide (1N, 0.8 ml) and ethanol (2 ml) was kept for 2 hours. The solution was evaporated and the residue dissolved in water (5 ml). Hydrochloric acid (1N, 0.8 ml) was added and the precipitate was filtered and washed with water and ether to give the title compound as a solid: m.p 305°-306° C.; m/e 342(M+H)+ ; NMR(d6DMSO) δ 8.0(2H,d); 6.72(6H,m); 3.74(2H,t); 3.3(4H,m); 2.94(4H,m); 2.19(2H,t); 1.72(2H, m); calculated for C19H23N3O3 : C, 66.8; H, 6.8; N, 12.3. Found: C, 67.0; H, 6.8; N, 12.2%.

後処理

  1. customThe solution was evaporated
  2. dissolutionthe residue dissolved in water (5 ml)
  3. additionHydrochloric acid (1N, 0.8 ml) was added
  4. filtrationthe precipitate was filtered
  5. washwashed with water and ether

出典と根拠

ORDレコード
ord-f32c2189fde44a52a00908f735c49175
出典データセット
uspto-grants-1998_03
特許番号
US05728701

関連ノート

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