Ammonium Chloride → 6-bromo-2-chloro-N3-methylpyridine-3,4-diamine
反応式
[Br:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([NH:9][CH3:10])=[C:4]([N+:11]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>C(O)C.O.CCOC(C)=O.[Fe]>[Br:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([NH:9][CH3:10])=[C:4]([NH2:11])[CH:3]=1参加物
7
反応条件
- 温度
- 140 °C
実験手順
To a solution of 6-bromo-2-chloro-N-methyl-4-nitropyridin-3-amine 2.59 (1 g, 3.75 mmol) in ethanol (10 ml) was added Fe powder (1.05 g, 18.7 mmol) and a solution of ammonium chloride (1 g, 18.8 mmol) in water (3 mL). The mixture was heated in microwave at 140° C. for 30 min. The mixture was then diluted with EtOAc, filtered and evaporated to give 6-bromo-2-chloro-N3-methylpyridine-3,4-diamine 2.59-A, which was used in the next step without purification.
後処理
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-2501c82646ee494491e5bc533971e776
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09376441B2
反応ノート
読み込み中…