Tetrahydrofuran → 2-(2-Amino-4-bromophenyl)propan-2-ol

HRID 2209288ノート

反応式

HRID 2209288 の反応式
C(O[C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:6]=1[NH2:12])(=O)C.[CH3:13][Mg+].[Br-].[CH2:16]1[CH2:20][O:19]CC1>>[NH2:12][C:6]1[CH:7]=[C:8]([Br:11])[CH:9]=[CH:10][C:5]=1[C:20]([OH:19])([CH3:16])[CH3:13]

参加物

4

反応物 3

HCID 8028Tetrahydrofuran2 回HCID 1178436442-Amino-4-bromophenyl acetateHCID 178418689HCID 178418689、化合物

生成物 1

HCID 571557062-(2-Amino-4-bromophenyl)propan-2-ol

実験手順

Into the solution of 2-amino-4-bromophenyl acetate (2.3 g) in THF (50 mL) was added 1M solution of MeMgBr in THF (50 mL) at 0° C. Then the reaction mixture was warmed to rt., and stirred for another 2 h. The reaction was quenched by saturated NH4Cl water solution, and extracted with ethyl acetate and washed with brine, after being dried, the solvent was removed to provide 2.3 g crude of 2-(2-amino-4-bromophenyl)propan-2-ol. This product was used in the next step reaction without any purification. LCMS [M+H]+: 231.86. 1H NMR (400 MHz, Chloroform-d) δ 7.26 (s, 1H), 6.95 (d, J=8.1 Hz, 2H), 6.81-6.73 (m, 3H), 1.64 (s, 6H).

後処理

  1. customThe reaction was quenched by saturated NH4Cl water solution
  2. extractionextracted with ethyl acetate
  3. washwashed with brine
  4. customafter being dried
  5. customthe solvent was removed

出典と根拠

ORDレコード
ord-1dc8bd9f19f444479e58a7db0303367b
出典データセット
uspto-grants-2016_06
特許番号
US09376441B2

反応ノート

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