p-Toluenesulfonic acid → Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate
反応式
[F:1][C:2]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[F:1][C:2]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]参加物
4
実験手順
41.4 g of the crude diethyl (2,4-difluorobenzoyl)malonate in 130 ml of water and 170 mg of p-toluenesulphonic acid are refluxed for 8.5 hours. The mixture is extracted using methylene chloride, and the methylene chloride phase is washed with water, dried over sodium sulphate and concentrated in vacuo.
後処理
- extractionThe mixture is extracted
- washthe methylene chloride phase is washed with water
- dry with materialdried over sodium sulphate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-004f342da97a46c88ff818f4982d3639
- 出典データセット
- uspto-grants-1995_10
- 特許番号
- US05457104
反応ノート
読み込み中…