Ammonia → HCID 178430719、化合物

反応式

N[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.[N+:9]([O-])([OH:11])=[O:10].N.S(=O)(=O)(O)[OH:15]>>[OH:15][C:2]1[C:7]([N+:9]([O-:11])=[O:10])=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1

参加物

反応物 4

HCID 222Ammonia

HCID 944Nitric Acid

HCID 1118Sulfuric Acid2 回

HCID 153482-Amino-5-methylpyridine

生成物 1

HCID 178430719HCID 178430719、化合物

反応条件

温度: 130 °C

実験手順

25 g of 2-amino-5-methylpyridine are dissolved in 50 cm3 of concentrated sulfuric acid in a 600 cm3 round- bottomed flask. A mixture consisting of 40 cm3 of concentrated nitric acid and 40 cm3 of concentrated sulfuric acid is progressively added. The reaction mixture heats up with formation of foam. The temperature is maintained constant at 130° C. throughout the duration of the addition of the acid. The colored solution is then poured onto 300 g of ice and the pH is brought to around 3-4 by addition of aqueous ammonia. After standing in a refrigerator, the precipitate obtained is collected on a filter, washed with water and dried. It is recrystallized from hot water.