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1-(Methoxymethyl)-6-phenylthiothymine → 5-Methyl-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Methoxymethyl)-6-phenylthiothymine | HCID 54016372 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 5-Methyl-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one | HCID 18671027 | 28.1% |
反応手順
To 100 ml of concentrated hydrochloric acid, 17.2 g (62 mmole) of 1-(methoxymethyl)-6-phenylthiothymine was added and allowed to react for 2 hours at 80° C. The reaction mixture was concentrated under reduced pressure and crystallized from ethanol to obtain 3.8 g of the target compound (Yield: 26%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05461060 |
| 出典データセット | uspto-grants-1995_10 |
| ORD ID | ord-0369532af2e4431695b46452e0db0fa1 |
| 出典メモ | uspto-grants-1995_10 |